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The quality of life of adults with ADHD
Česlová, Karolína ; Herink, Josef (advisor) ; Kudláčková, Zděnka (referee)
The thesis deals with the issue of ADHD (Attention Deficit Hyperactivity Disorder) in the adult population with the aim of finding out how this disorder manifests itself in the everyday life of an adult, whether it affects him/her and to what extent. Information was obtained from 37 already diagnosed adult men and women who voluntarily participated in the research in the form of a structured multiple-choice questionnaire. The findings gathered were then evaluated, compared with available experience and also contributed to answering the questions I had previously considered. Thanks to the answers and its closer examination from the people so diagnosed, it appears that this disorder interferes with their daily lives, affecting their actions and their very quality of life. Awareness of ADHD in adulthood among both the general public and, to some extent, the professional public is still relatively low.
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Neurobiology and toxicity of new psychoactive substances from hallucinogens class
Zmátlo, Vít ; Leca, Nikola (advisor) ; Novotný, Jiří (referee)
Main focus of this thesis are the novel synthetic psychoactive substances from hallucinogens class. The first part expands the phenomenon of hallucinogens and describes its general mechanisms. Serotonergic system is emphasised with focus on 5-HT2A receptor as a main moderator of hallucinogenic aktivity. Next part enlightens the issue of new psychoactive substances and elaborates on two main classes of hallucinogens - tryptamines and phenylethylamines, with epmhasis on their synthetic derivates. There is described the form of occurence, relationship between chemical structure and biological activity, and current knowledge of neurobiology toxicity of those substances. Key words: New psychoactive substances, hallucinogens, serotonergic system, neurobiology, toxicity
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